Confocal microscopy unambiguously visualise nanoparticles NOT penetrating skin surface

The Bath study (“Objective assessment of nanoparticle disposition in mammalian skin after topical exposure”) discovered that even the tiniest of nanoparticles did not penetrate the skin’s

“Using confocal microscopy has allowed us to unambiguously visualise and objectively assess what happens to nanoparticles on an uneven skin surface. Whereas earlier work has suggested that nanoparticles appear to penetrate the skin, our results indicate that they may in fact have simply been deposited into a deep crease within the skin sample.
“The skin’s role is to act as a barrier to potentially dangerous chemicals and to reduce water loss from the body. Our study shows that it is doing a good job of this.
“So, while an unsuspecting consumer may draw the conclusion that nanoparticles in their skin creams, are ‘carrying’ an active ingredient deep into the skin, our research shows this is patently not the case.”
The results of the work suggest that it might be possible to design a new type of nanoparticle-based drug formulation that can be applied to the skin and give controlled release of a drug over a long period of time.
This would enable sustained delivery of the active drug, potentially reducing the frequency with which the patient would have to apply the formulation to the skin.

Source: University of Bath

The Bath study (“Objective assessment of nanoparticle disposition in mammalian skin after topical exposure”) discovered that even the tiniest of nanoparticles did not penetrate the skin’s surface.

http://www.nanowerk.com/news2/newsid=26857.php

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