Sir John B Gurdon has won the Nobel Prize in Physiology or Medicine 2012 for his discovery in 1962 at the University of Oxford that the specialisation of cells is reversible.
It was while he was at Oxford’s Department of Zoology that he carried out a classic experiment in 1962.
He hypothesised that the genome of a mature cell might still contain all the information needed to drive its development into all the different cell types of an organism. He replaced the immature cell nucleus in an egg cell of a frog with the nucleus from a mature intestinal cell. This modified egg cell developed into a normal tadpole. The DNA of the mature cell still had all the information needed to develop all cells in the frog.
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