Chemical probes inadequately characterized

Potent, selective and cell-permeable inhibitors of protein function “chemical probes” are valued reagents in both fundamental and applied biological research, and they are essential for preclinical target validation in academic and industrial laboratories. However, chemical probes are not widely available because they are difficult to produce without access to skilled medicinal chemists; they are also frequently targeted to the relatively few proteins that have already been the focus of industrial drug discovery efforts and are often encumbered by intellectual property and restrictive material transfer agreements. Moreover, many of the probes currently available are inadequately characterized and nonselective, and thus are used inappropriately by the research community.

Aled Edwards et al, Nature Chemical Biology, Vol 5 (7), pp 436, (2009)


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